Abstract
Objective : To evaluate met-enkephalin levels in women with intrahepatic cholestasis of pregnancy (ICP) by comparison to healthy controls and compared the pregnancy outcomes.
Method: This cross-sectional study was conducted in 43 pregnant women with ICP and 40 randomly selected healthy pregnant women, who formed the control group.Serum met-enkephalin concentrations were measured using an enzyme-linked immunosorbent assay. The patients’ age, body mass index (BMI), gestational week, fasting serum bile acid, serum parameters, birth week, and APGAR scores at 1st and 5th minutes were recorded.
Results: Maternal age, BMI and gestational age at blood sampling were similar between the two groups. Considering the pregnancy outcomes, birth week was significantly lower in the ICP group than the control group (37 vs. 38 weeks, respectively; p
Key words: cholestasis, bile acids, opioid, pregnancy, pruritus
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