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Review Article

JCR. 2020; 7(1): 115-118

Study the effect of zinc oxide ointment on symptoms arising from hemorrhoids and anal fissure

Setareh Soltany, Babak Hosseinzadeh Zoroufchi.

Introduction: Anal fissure and hemorrhoids are the most common anorectal complaints. According to the prevalence of these diseases and the complications of their surgical treatments, attempts to relieve the symptoms of the disease with medical treatments, including the use of topical agents, are ongoing. This study was performed to study the effect of zinc oxide ointment on symptoms arising from hemorrhoids and anal fissure.
Materials and Methods: In a randomized clinical trial on patients with hemorrhoids and anal fissure referred to Amir al-Momenin hospital surgery clinic, 108 patients were examined in two groups. In the intervention group (n = 53) patients received zinc oxide ointment and in the control group (n = 55) placebo received vaseline in the anus area twice a day for one month. In addition, sitz bath and high fiber diet were recommended to all patients. At the end, the rate of pain reduction, bleeding and itching were compared between the two groups.
Results: The results showed that at the end of the study, the mean pain rate, mean bleeding per day and mean itching severity in all patients were significantly decreased in both groups. However, this difference was not significant in the case (control) and control (placebo) groups, and likewise in the fissure and hemorrhoid patients in the case and control groups.
Conclusion: Medical treatment helps relieve symptoms in most fissure and hemorrhoids patients. In this treatment, topical use of zinc oxide ointment is not superior to vaseline, and both zinc oxide ointment and vaseline are effective as a part of medical treatment.

Key words: Hemorrhoids, Anal fissure, Zinc oxide.

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