Background: The incidence of depressive disorder statistics has increased in every year; it differs from county to county and risk factor is also differed between country and lifestyle modification, cultures. Depression is a serious health problem in worldwide including India. Due to the present utilizing antidepressant drugs, a variety of upsetting symptoms. Amid the most recent decade, the disclosure of more secure stimulant natural cures is on the rise. Tricholepis glaberrima has been utilized in ancient people prescription different diseases incorporating central nervous system disorders in Ayurveda.
Aims and Objectives: The study was aimed to investigate the persistent behavioral antidepressant activity of T. glaberrima bark alone and in combination with Mimosa pudica root extract.
Materials and Methods: Ethanolic extract of T. glaberrima bark and M. pudica root extracts was prepared followed by analysis of phytochemical constituents was determined using appropriate biochemical method, acute toxicity studies also performed, and the biological investigation of both plants extracts was conducted through pharmacological screening models (forced swimming test and tail suspension test) in Swiss albino mice. Sixty trained animals were divided into six groups, each group six animals allotted (n = 6), Groups-1 and 2 served as vehicle control and imipramine (15 mg/kg), respectively, Groups-3 and 4 were treated 200 mg/kg and 400 mg/kg of Ethanolic extract of T. glaberrima bark (ETGB), and Group-5 was treated ETGB 100 mg/kg and Ethanolic extract of M. pudica root (EMPR) 100 mg/kg extracts; Imipramine was used as reference standard control. Following 14 days chronic treatment with acute restrain stress induced. All animals were tested using behaviors depression screening models.
Results: The study shown significant (P < 0.0001 [at 1% level]) improvement in chronically treated mice in both screening models. Group V shown significant improvement compare to alone ETGB treated groups.
Conclusion: The results suggest that this combination groups can be potential antidepressant effect. However, further mechanistic studies are required to confirm the cellular action and therapeutic efficacy of ETGB and EMPR against depression.
Key words: Antidepressant; Mimosa pudica; Tricholepis glaberrima; Forced Swimming Test; Tail Suspension Test
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