Nosocomial infections are defined as those that occur beyond 48 hours after birth and are caused
by pathogens that are not maternally derived. Such infections are 100 times more common than early-onset
bacterial infections, which are caused by pathogens acquired in utero or perinatally. The morbidity and
mortality from nosocomial infections is enormous. In the United States, more than 2,000,000 nosocomial
infections (in infants and adults) occur each year, and 50% to 60% are caused by resistant organisms. Over
the past 50 years, the epidemiology of pathogens responsible for nosocomial infections in neonates has
changed dramatically. Bacterial Pathogens are responsible for Nosocomial infection - Coagulase-negative
Staphylococci, Staphylococcus aureus, Enterococci, Pseudomonas Aeruginosa. Strategies for Prevention
of Nosocomial are asepsis, hand washing/"degerming, skin antisepsis, antibiotic prophylaxis
Key words: Nosocomial Infection and NICU.
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