Abstract:
The leaves of Trema guineensis (Schum. & Thonn) Ficalho are used in traditional Togolese medicine as antihypertensive remedy. This study aims to evaluate the protective effect of Trema guineensis extract on glucose-induced hypertension at Wistar rats. Hypertension was induced in rats by oral administration of 10% D-glucose for 3 weeks. Animals received treatments for three weeks. At the end of the treatments, Blood Pressure, reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), oxide nitric (NO) activity in heart, aorta, liver and kidney and biochemical parameters in serum were measured. At the doses of 200 and 400 mg/kg/day Trema guineensis has significantly prevented the increase in mean blood pressure in presence of glucose. The extract has significantly prevented the high concentrations of total cholesterol, and triglycerides, LDL, atherogenic index, urea, uric acid induced by glucose treatment as compared to the untreated glucose rats group. Trema guineensis (400 mg/kg) prevented the increase of GOT, GTP but didnt affect serum creatinine levels. Treatment with plant extract significantly prevented the increase of SOD, MDA, and the decrease of GSH and NO concentration in aorta, heart, kidney and liver. These results have demonstrated that the extracted leaves of Trema guineensis could prevent glucose-induced hypertension. These results have allowed the traditional use of Trema guineensis.
Key words: Trema guineensis, hypertension, antioxidant, Wistar rat,glucose
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