This study was performed to assess potential efficacy of Coenzyme Q10 (CoQ10) to restore oxytetracycline (OXT)-induced toxicity. Rats were distributed into four equal groups (6 each). Control group (rats were orally administered 0.5 ml propylene glycol). CoQ10 group (rats were orally administered 10 mg/kg BW Coenzyme Q10). OXT group (rats were injected intraperitoneally with 200 mg/kg BW oxytetracycline hydrochloride). OXT+CoQ10 group (rats were given the combined treatments). Treatments were used daily for seven days. Results indicated that OXT induced significant changes in serum biochemical parameters, significant increase of lipid peroxidation and exhaustion of reduced glutathione and catalase in liver, kidney and testis. Also, OXT reduced serum testosterone levels besides sperm motility and viability. Histopathological changes were marked in liver, kidney and to some extent in testis and epididymis. CoQ10 treatment restored oxidative stress in liver, kidney and testis, improved serum testosterone levels, sperm motility/viability as well as histopathological alterations. In conclusion, short term administration of OXT induced hepatorenal and male reproductive toxicity through oxidative stress. This study is the first to suggest that CoQ10 could provide partial protection against OXT-induced hepatorenal/reproductive toxicity in male rats.
Key words: Coenzyme Q10, Oxytetracycline, Oxidative stress, Histopathology
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