Background: Diabetes mellitus is a group of metabolic disorder characterized by chronic hyperglycemia with disturbances in carbohydrate, fat, and protein metabolism due to defects in insulin secretion, insulin action, or both. Diabetic dyslipidemia is characterized by increases low-density lipoprotein cholesterol (LDL-C), decreased high-density lipoprotein cholesterol (HDL-C) level, and elevated triglyceride (TG) levels.
Objectives: The objectives of this study were to correlate the lipid profile with age, gender, and body mass index (BMI) of type 2 diabetes mellitus (T2DM) patients.
Materials and Methods: A total of 76 T2DM patients were studied at Diabetes, Obesity, and Thyroid Center, Gwalior, Madhya Pradesh, between May 2016 and May 2017. After detailed demographic details including age, sex, weight, height, and BMI, total cholesterol (TC), TG, LDL-C, very LDL-C (VLDL-C), and HDL-C were estimated for all the patients.
Results: The mean age of diabetes patients was 54.80 ± 11.07 years. The mean duration of diabetes was 5.38 ± 4.90 years. Lipid profile of T2DM patients was similar across the different age and BMI groups (P > 0.05). Except HDL-C (P < 0.001) which was significantly low among males other lipid parameters such as TC, TG, LDL-C, and VLDL-C were comparable between genders (P > 0.05). TC, TG, LDL‑C, and VLDL-C were showed positive correlation with fasting plasma glucose and postprandial glucose, whereas HDL-C showed negative correlation (P > 0.05).
Conclusion: There was no significant difference in TC, TG, HDL-C, LDL-C, and VLDL-C level between different age and BMI groups. We found a significantly lower HDL-C level among the male population.
Key words: Abnormal Lipid Profile; Dyslipidemia; Type 2 Diabetes Mellitus; Cardiovascular Disease
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