Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



Correlation of plasma fibrinogen and lipoproteins in diabetic hypertensive patients

Niranjan Rachaiah, Vijay Malleshappa.




Abstract

Background: Diabetic hypertensive patients have higher cardiovascular morbidity and mortality than general population. Various risk factors like age, BMI (Body mass index), hypertension, smoking, dyslipidemia, etc. have been extensively studied, but still these together cannot explain increased cardiovascular morbidity and mortality in diabetes. Several studies have shown that fibrinogen is a powerful independent risk factor for cardiovascular disease. Hence fibrinogen levels
and its correlation to lipoproteins in diabetic hypertensives were studied.

Objective: To estimate plasma fibrinogen levels in patients with type 2 diabetes mellitus and hypertension and to correlate plasma fibrinogen with Lipoproteins and also with BMI.

Materials and Methods: A Prospective cross sectional study conducted in a tertiary carehospital. Data collected by simple random sampling method and analysis of various parameters done by using chi square-test and correlated with pearson’s correlation coefficient “r”.

Results: The higher plasma fibrinogen levels were found in diabetic hypertensives (449.06 ±131.26) when compared to controls. The mean total cholesterol, TG (triglycerides), LDL (Lowdensity lipoprotein), VLDL (Very low density lipoprotein), HDL (High density lipoprotein) among cases were 195.82 ± 26.92 mg/dl, 243.62 ± 45.83 mg/dl, 104.15 ± 25.76 mg/dl, 48.72 ± 9.17 mg/dl, 38.21 ± 4.03 mg/dl respectively and the mean BMI of cases was 26.16 ± 5.36 kg/m2. The plasma fibrinogen is positively correlated to BMI and total cholesterol levels which is statistically significant.

Conclusion: The plasma fibrinogen levels could potentially be considered for screening programs to identify people at high risk of vascular events.

Key words: Plasma fibrinogen; Lipoproteins; Diabetic Hypertensive; BMI






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.