Although paradoxical mania/hypomania due to antidepressant withdrawal is rarely reported in the literature as case report, it is possible that it may be observed more commonly in the clinical settings. Paradoxical mania/hypomania is reported to be associated with tricyclic antidepressants as well as selective serotonin reuptake inhibitors and other antidepressants. Although paradoxical mania/hypomania due to sertraline and paroxetine withdrawal are reported individually, we will discuss a patient with paradoxical mania/hypomania due to withdrawal of both antidepressants administered at two different time periods, since this is the only case reported so far.
Key words: Antidepressant discontinuation, hypomania, mania, paroxetine, sertraline
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