Objective: The etiology of non-alcoholic fatty liver disease (NAFLD) is still not clearly defined. Carbohydrate metabolism disorder including prediabetes to overt diabetes constitutes the main stone of the NAFLD. However; data on the relationship between glycemic disorders and NAFLD is scarce. Recent studies show that alanine transaminase (ALT) and gamma-glutamyl transferase (GGT) levels can be predictor factors for NAFLD. The relationship between hepatic test and prediabetes has not been defined clearly, yet. Therefore; we evaluated whether the intermediate stages of oral glucose tolerance test have association with NAFLD and with hepatic function test.
Materials and Methods: 75 gr oral glucose loading test and hepatic function levels were evaluated in 367 participants. Hepatosteatosis level were assessed with ultrasonographic evaluation.
Results: Grade of hepatic steatosis was positively correlated with age, body mass index (BMI), 60. min blood glucose, ALT, GGT and weakly positively correlated with fasting blood glucose, 0. min blood glucose. In lineer regression analysis, 60. min blood glucose after glucose loading were obtained to be an independent risk factor for NAFLD regardless of age, BMI.
Conclusion: NAFLD is extremely common in people with carbohydrate metabolism disorder and is mainly associated with glucose levels. The 60. min blood glucose levels after post challenge test might have been a role in etiopathogenesis of NAFLD. ALT and GGT levels are also associated with glucose levelsat one-hour glucose loading and hepatosteatosis degree.
Key words: One-Hour Glucose Levels; Oral Glucose Tolerans Test; Non-Alcoholic Fatty Liver Disease; Hepatic Function Test.
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