Home|Journals|Articles by Year|Audio Abstracts
 

Original Article

Open Vet J. 2022; 12(2): 231-241


Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system

Joana Matos, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, Miguel Campos.




Abstract
Cited by 0 Articles

Background: Hyperthyroidism is the most frequent endocrinopathy in older cats. To date, there is no consensus on how to best calculate the dose of radioiodine to administer to hyperthyroid cats.
Aim: The goals of this study were to compare thyroid function, renal function and survival time between hyperthyroid cats receiving a fixed dose of radioiodine and those receiving an individualized dose calculated using a clinical scoring system.
Methods: Medical records of 110 cats treated with radioiodine therapy at the University of Bern between 2010 and 2020 were reviewed. Thyroid function, renal function and survival of cats treated with a fixed dose of radioiodine (2010-2015; n= 50) were compared to those of cats treated with an individualized dose (2015-2020; n= 60) at different timepoints after therapy.
Results: Treatment with a fixed dose of radioiodine (mean 168 ± 26 MBq) was associated with 69% of euthyroidism, 19% persistent hyperthyroidism and 12% hypothyroidism, whereas treatment with an individualized dose (mean 120 ± 30 MBq) led to 54% euthyroidism, 23% hyperthyroidism and 23% hypothyroidism (P=0.73).
More than twelve months after treatment, the incidence of azotaemia was comparable between cats treated with a fixed dose (37%) and those treated with an individualized dose (31%) (P= 0.77).
No factors were found to be predictive of treatment failure (hypothyroidism or hyperthyroidism) after therapy.
Median survival time after radioiodine therapy was 44 months. In a multivariate analysis, persistent hyperthyroidism was the only variable independently associated with a shorter survival time (HR= 6.24, P= 0.002).
Conclusion: The method of calculating the dose of radioiodine (fixed vs individualized) to treat feline hyperthyroidism does not appear to be decisive for post-treatment thyroid function, renal function or survival.

Key words: cat; dose; hyperthyroidism; radioiodine.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.