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Original Research

Ann Med Res. 2007; 14(3): 149-155


Effect of Sevoflurane and Isoflurane Anaesthesia on Cognitive Function in Early Postoperative Period

 

Berrin Işık*, Zafer Pamukçu*, Ayşin Alagöl*

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Abstract


 

Aim: Cognitive functions are affected after general anaesthesia to varying degree. In this research we aimed to evaluate of sevoflurane versus isoflurane anaesthesia effects on cognitive function in recovery period.

Material Method: This clinical research was performed on ASA I-II groups, ages between 17–73 years, totally 62 patients, who had at least 8 years of education, who planned to have elective surgical operations under general anaesthesia. Patients were randomly assigned to receive sevoflurane or isoflurane anaesthesia. Before the induction of anaesthesia, the Short Cognitive Examination Test (Kısa Kognitif Muayene Testi) performed and the scores were noted down as preoperative scores. Anaesthesia induction was provided with propofol and atracurium and continued with sevoflurane (Group S) or isoflurane (Group I) inhalation. During operation period, heart beat rates, blood pressure, saturation of oxygen, end tidal CO2 pressure were monitored. Furthermore blood gases, glucose, BUN, electrolyte values were measured from blood samples taken on 30th min of operation. Fifteen and 60 min after extubation Short Cognitive Examination Test performed again. Evaluated data were compared statistically.

Results and conclusion: Preoperative and postoperative 60 min Short Cognitive Examination Test scores, cardio-respiratory and biochemical variables were within normal range and similar between groups. However mean values of Short Cognitive Examination Test on postoperative 15th min were lower than initial values and below normal limits in both groups. This decline was more significant in Isoflurane Group than Sevoflurane Group (p≤0.05).

It is concluded that both inhalation agents adversely affect cognitive function on postoperative 15th min however decline in Isoflurane Group is higher; and that in both groups normal limits on postoperative 60th min.

Key Words: Anaesthesia, Cognitive function, Recovery, Sevoflurane, İsoflurane






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