Background: One of the reasonable goals for HIV chemotherapy is to get the most effective drugs with minimal or negligible side effects in the long run.
Aim: This study was designed to investigate the short term effects of stavudine, lamivudine and nevirapine on serum lipids of HIV-1 positive subjects in Benin City, Nigeria, between three and six months of usage.
Methods: Test group 1 (n=78) and test group 2 (n= 71) comprised HIV- 1 seropositive individuals on HAART for a period of one to three months; and five to six months respectively. Fifty five newly diagnosed HIV-1 positive subjects naïve to HAART served as control group 1 and sixty apparently healthy HIV-1 seronegative individuals served as control group 2. The blood samples obtained were analyzed for total cholesterol, triglycerides, low density lipoprotein and high density lipoprotein using standard enzymatic methods.
Results: Mean total cholesterol concentration of test group 2 (214.0±6.43mg/dL) was not significantly different from Test group 1 (202.4±5.09mg/dL), both were however significantly higher than control group 1 (159.3±5.09mg/dL) and control group 2 (101.6±3.76 mg/dL); p
Key words: Dislipidaemia, HIV chemotherapy (HAART), Lipid profile, HIV
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