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Egypt. J. Exp. Biol. (Zoo.). 2009; 5(0): 353-362


ROLE OF 2-MERCAPTOPROPIONYLGLYCINE IN TREATMENT OF LEAD TOXICITY IN RATS WITH RENAL DYSFUNCTION

Mohamed A. Basyony.




Abstract

The present study was conducted to evaluate the extent of lead pollution at Assiut district and to assess its toxic effects on uremic rats and the potential role of 2- Mercaptopropionyl glycine (2-MPG) in their management. The extent of lead pollution was assessed by analysis of water and soil samples, tissues in some species of fishes and plants in the study area. The metal toxicity was monitored by determination of the LD50 of lead for normal and for renal disordered rats, mortality curves, metal tissue accumulation, total body weight gain and relative weight of kidney. The effect of chronic (5 and 50 mg Pb/kg/dayx30) and acute (LD50 and 1/2 LD50) administration of lead on kidney functions of rats with renal disorder were determined. The protective role of 2-MPG at a dose regimen of 50mg/kg / day x30 in management of the toxic effects resulting from the chronic and acute administration of lead was also assessed. Compared to internationally permissible level (0.05 mg/l), the study showed no apparent degree of lead pollution of water except samples taken from the industrial area around Menkbad Fertilizer Factory (0.955 mg/l). Tissue plant analysis showed that metal accumulation was found to be correlated to the extent of soil pollution with the highest accumulation in Morus album (65.168 mg/kg) followed by Imperata cylindrica (59.748 mg/kg). Fish tissue analysis showed a degree of metal accumulation in different tissues of the Clarias lazera particularly in its gills (7.89 mg/kg). The study showed that lead is more toxic to uremic rats (LD50 of 1870 mg/kg) than to normal ones (LD50 of 3200 mg/kg). Mortality rate due to lead intoxication was higher in uremic rats than normal ones. In uremic rats, lead intoxication displayed further disorders on kidney functions compared with non-intoxicated ones as manifested by disturbances in alkaline phosphatase activity in kidney as well as serum urea and serum creatinine levels. The toxic effects of lead were found to be more severe in acute rather than in chronic treatment. Administration of 2-MPG displayed appreciable protective effect against lead toxicity in uremic rats as manifested by reductions of renal disorders, tissue lead accumulation and mortality rate.

Key words: 2-Mercaptopropionylglycine, Environmental pollution, Lead toxicity, Renal disorder






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