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Egypt. J. Exp. Biol. (Zoo.). 2007; 3(0): 211-217


REPAIR OF CARBON TETRACHLORIDE-INDUCED RAT LIVER INJURY BY GINGER EXTRACT (ZINGIBER OFFICINALE)

Dalia Fouad Afifi Abou-Zaid.




Abstract

Carbon tetrachloride is the organic compound that is widely used in fire extinguishers, as a precursor to refrigerants, and as a cleaning agent. The medicinal properties of Ginger (Zingiber officinale) are attributed to its anti-arthritic, anti-migraine, anti-thrombotic, anti-inflammatory, hypolipidaemic, hypocholesterolaemic, and anti-nausea properties. Treating albino rats with Carbon tetrachloride induced various histological changes in the liver. These changes include congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolization of the hepatocytes and pyknosis. Administration of carbon tetrachloride decreased the total serum protein and globulin, besides it increased the serum albumin value and significantly increased the albumin/globulin ratio. Treating animals with ginger extract ameliorate the total protein, albumin, globulin, and the ratio of albumin to globulin. Moreover, ginger led to an improvement in the histological liver picture. The results of the present work indicated that the ameliorative effect of ginger against liver damage induced by Carbon tetrachloride is mediated by its potent antioxidant activities.

Key words: CCl4, Liver, Rat, Histopathology, Albumin, Globulin, Albumin/Globulin ratio.






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