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Original Article

J. Islam. Int. Med. Coll.. 2018; 13(4): 184-188


Effects of Aqueous and Methanolic Extracts of Cichorium Intybus Seeds on Gentamicin Induced Nephrotoxicity in Rats

Muhammad Tahir, Noman Sadiq, Sameer Ahmed, Amanat Ali, Noor Nasir Rajpoot, Uzma Riaz.


Abstract

Objective: To evaluate the effects of Aqueous and Methanolic extracts of Cichorium Intybus seeds on
Gentamicin induced nephrotoxicity in rats.
Study Design: Experimental Study
Place and Duration of Study: Study was conducted from 15 January to 31 March 2017 at National Institute of
Health Sciences (NIH) in collaboration with Riphah Institute of Pharmaceutical Sciences (RIPS).
Materials and Methods: Forty healthy Sprague Dawly rats weighing 300-350gms were randomly divided in four
groups with 10 rats each. Group A was the control group that received no medications. Group B was given
Gentamicin 80mg/ kg body weight / day for 10 days intraperitoneally (IP). Group C was given Gentamicin 80mg/
kg body weight / day IP and Aqueous Extract of Cichorium Intybus seeds 500mg/kg body weight/ day through
gavage tube for 10 days. Group D was given Gentamicin 80mg/ kg body weight / day IP and Methanolic Extract
of Cichorium Intybus seeds 500mg/kg body weight / day through gavage tube for 10 days. Serum urea and
creatinine were measured at day zero, 6, and 11. The values were compared within and between the groups.
Results: Elevated levels of serum urea and creatinine were found in group B indicating renal damage. Whereas
administration of Aqueous and Methanolic extracts of Cichorium Intybus seeds reduced the elevated levels of
serum urea and creatinine in group C & D. However more reduction was produced in group C.
Conclusion: Concomitant administration of Aqueous and Methanolic extracts of Cichorium Intybus seeds
exerted nephroprotective effect on Gentamicin induced nephrotoxicity in rats. Aqueous extract produced
greater protection as compared to Methanolic extract.

Key words: Cichorium Intybus Seeds, Gentamicin, Nephroprotective effect, Nephrotoxicity.






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