Objective: To determine the association between hypothyroidism and metabolic syndrome
Study Design: Observational cross sectional study
Place and Duration of Study: Data was collected from Medical unit and Department of Pathology, Pakistan
Railways Hospital, Islamic International Medical College, Rawalpindi and Capital Hospital Islamabad from April
2017 to April 2018.
Materials and Methods: One hundred and fifty adult subjects participated in this study. Hundred hypothyroid
subjects were recruited as cases on the basis of laboratory findings of raised serum thyroid stimulating
hormone (TSH) levels and low serum free thyroxine (FT4) level. Newly diagnosed/ untreated cases of
Hypothyroidism and adults of either sex were included. After an overnight fasting, participants were tested for
various components of metabolic syndrome. Fifty euthyroid subjects were taken as controls. Data was analyzed
Results: Among 150 total recruited subjects, 25% hypothyroid cases and 10% euthyroid controls were
diagnosed with metabolic syndrome. These results were statistically significant with p value 0.030. Mean
serum triglycerides 183 ±26 and 153±26 mg/dl and mean fasting blood glucose 100 ±30 and 96 ±18 mg/dl
respectively among hypothyroid and euthyroid patients were significant with p-value 0.001. Whereas, waist
circumference, high density lipoprotein cholesterol and blood pressure measurement of hypothyroid and
euthyroid individuals were not significant.
Conclusion: Hypothyroidism is associated with various components of metabolic syndrome.
Key words: Free Thyroxine, Fasting Blood Glucose, Hypothyroid, Metabolic Syndrome, Serum Triglycerides,
Thyroid Stimulating Hormone