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Review Article

SRP. 2020; 11(4): 175-187


Antitumor, Antioxidant, and Antibacterial Activities of Glycosyl-Conjugated Compounds: A Review

Moath Kahtan Bashir, Yasser Fakri Mustafa, Mahmood Khudhayer Oglah.

Abstract
There is a developing interest for the utilization of glycosyl-conjugation to improve the biological and pharmacokinetic properties of different medicinally active products. This is manifested by the presence of a significant number of research papers concerning the boosting of various therapeutic potentials of known drugs by their conjugation with different mono-, di-, or poly-saccharides. This review summarizes the most important and most recent examples of this conjugation, especially those related to the enhancement of antitumor, antioxidant and antibacterial activities of the original drugs. These examples with the proposed mechanisms of activity improvement may guide to design, synthesis and evaluation of new glycosyl-conjugates for better therapeutics.

Key words: Glycosylation, Antitumor, Antioxidant, Antibacterial.


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