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Research Article

JCDR. 2021; 12(6): 1544-1555

Effect of Glycemic Control on the Occurrence of Coronary In Stent Restenosis

Ahmed S. Eldamanhory, Mohammed Sobeih, Ahmed S.Ammar, Islam A. Elsherbiny, Mohamed Saad El-Shetry, MoatazElSanan.


The clinical outcome after PCI among patients with diabetes is less favorable than the
outcome among non-diabetic patients. Purpose:Tounderstand the importance of the
diabetes control in the diabetic patients who had PCI, so they can receive better
management and avoid the occurrence of in stent restenosis.Patients and methods:In
thiscomparative cross sectionalstudy we included 130diabetic patients who have been
admitted to zagazig university hospital cath lab for undergoing an invasive coronary
angiography. All of them had a history of old PCI. Patients then were were divided into 2
groups: ISR group (n=38) and no ISR group (n=92) then comparison of both group
regarding Hb1Ac and other demographic, laboratory, and angiographical findings.
Results:Higher levels of HbA1C as well as higher values of systolic blood pressure were
found in the ISR group when compared to the No-ISR group (P= 0.03, 0.001
respectively).That means patients with uncontrolled DM and patients with uncontrolled
HTN developed more ISR. Patients in ISR group had higher Hs-CRP values compared to
the No-ISR group (P < 0.001). Moreover, Patients in the ISR group had more coronary
lesions of type C (P= 0.013) compared to the No-ISR group.
Conclusion:In summary, this study found that in-stent restenosis is significantly greater
in those patients having greaterHbA1C.

Key words: Stent -Restenosis – Coronary – HbA1C – Diabetes - control

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