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Evaluation of Effect of Halquinol on Intestinal Motility in Rats

Pavithra, B. H., Prakash, N., Santhosh, C. R., Leena, G., Suguna Rao, Rashmi, R..


Abstract

Effect of halquinol on intestinal motility was determined by charcoal meal test in Wistar rats. The three treatment groups received halquinol @ 200, 400 and 1000 mg/kg b. wt., P.O. The rats of three treatment groups were also pre-treated with halquinol twice a day at 12 hrs interval for six days at their respective doses. On seventh day, charcoal meal test was carried out. The distance of the small intestine travelled by charcoal meal in rats belonging to 1000 mg/kg b. wt. treatment group was 44.5±8.22 cm which is less compared to control group (61.33±6.39 cm), which reflects decrease in intestinal motility. And peristalsis index in 1000 mg/kg b. wt. treatment group rats was 0.50±0.09 which is comparable to that of the standard group rats whose peristalsis index is 0.37±0.03. Charcoal meal test in the present study indicated that halquinol possess antimotility effect upon pre-treatment with halquinol @ 1g/kg b.wt.

Key words: Charcoal Meal Test, Halquinol, Intestinal Motility, Wistar Rats






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