During sepsis along with the manifestation of symptoms, there are many biochemical and physiological changes in the host. To mark a few are the Presence of bacteria, changes in overall proteomics of blood, which is termed acute phase response, and organ failure leading to death in extreme cases. In search for biomarkers during early bacterial infection, we could identify a prominent biomarker Neutrophil gelatinase-associated lipocalin (NGAL), and its involvement in bacterial infection. NGAL is a 25 kDa protein secreted by neutrophils, whose importance is well studied in kidney injury and cancer, whereas its role during bacterial infection is less sorted. To evaluate its role, human whole blood cells (HWBC) induced with bacterial E. coli LPS were analyzed for changes in NGAL expression. NGAL transcripts were observed to be upregulated very early,
Key words: Lipopolysaccharide, Acute phase proteins (APP), Antibacterial compounds, Anti apoptotic proteins
|
