Introduction: Pseudomonas aeruginosa is one of the most common hospital – acquired infections in our setups.
Due to increasing resistance of the organism, the mortality and morbidity of the patient is also increasing.
Detection of the organism is very important to manage the diseases caused by organism.
Objective: To evaluate the in vitro efficacy of various anti-Pseudomonas antibiotics by paper disk diffusion
method against Pseudomonas aeruginosa isolated from various clinical specimens and to identify appropriate
antimicrobial in our setups.
Patients and Methods: It was a prospective study conducted at Department of Pathology, Indus Medical
College Tando Muhammad Khan for the period of 6 months. A total of 103 strains of Pseudomonas aeruginosa
were studied using various clinical specimens. Antimicrobial agents used were Carbenicillin (CAR), Piperacillin
(PIP), Imipenem (IMI), Aztreonam (AZT), Gentamicin (GEN), Tobramycin (TOB), Amikacin (AMI),
Ceftazidine (CAZ), Ofloxacin (OFL), Cipiprofloxacin (CIP) and Enoxacin (ENO).
Results: Amikacin, Ceftazidime, Imipenem, Pipercillin, Aztreonam, Ciprofloxacin, Enoxacin, Carbenicillin,
Ofloxacin, Tobramycin and Gentamicin were sensitive in percentages as92.23%, 87.3%), 83.5%, 80.6%, 73.7%,
64%, 60%, 53.3%, 47.5%, 40.7% and 39.8 % respectively.
Conclusion: This study shows that use of Carbenicillin, Ciprofloxacin, Enoxacin, Ofloxacin, Tobramycin and
Gentamicin against Pseudomonas aeruginosa on empirical basis will not be without the risk of treatment failure.
Pseudomonas aureginosa, antibiotics, hospital – acquired infections