Introduction: Escherichia coli the most prevalent organism which causes urinary tract infections in both
hospital acquired and community acquired setups. Due to misuse and extensive use of antibiotics, resistance to
antimicrobial agents are increasing worldwide, which is the cause of complicated and uncomplicated urinary
Objective: The main aim and objective of this study is to detect the susceptibility of antimicrobial agents
against clinical isolates of Escherichia coli from the patients suspected with urinary tract infections.
Study Design: Prospective study
Place and Duration of Study: This prospective study was conducted at Indus Medical College Tando
Muhammad Khan's Department of Pathology and Microbiology for six months from September 2020 to
Material and methods: It was prospective cross – sectional study performed at Department of Microbiology
Indus Medical College Tando Muhammad Khan. It was conducted for a period of 6 months. A total of 103
positive urine samples were studied from suspected patients of UTI. The susceptibility of antimicrobial agents
was detected using Kirby-Bauer disc diffusion method.
Results: Among 103 isolates, 61 (59.22%) were female and 42 (40.77%) were male. Mean age of patients was
42.2 years. Sensitive susceptibility of isolates were: Imipenum (99%), Amikacin (98%), Nitrofurantoin (92.2%),
Ceftazidime (80.5%), Aztreonam (77.6%), Norfloxacin (55.3%), Ciprofloxacin (55.3%), Nalidixic acid (29%),
Cotrimoxazole (27%), Piperacillin (19.4%), Ampicillin (13.6%) and Keflax (9.7%).
Conclusion: E. coli was sensitive against Imipenum, Amikacin and Nitrofurantoin. Although other antibiotics
showed variable sensitivity patterns. Use of appropriate antibiotic according to sensitivity of microorganism is
very important to reduce to resistance microorganisms against antimicrobial agents.
Escherichia coli, urinary tract infections, isolates, sensitivity, resistance.
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