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Non-invasive assessment of endothelial function of systemic arteries during obstructive chronic bronchopneumopathy in African Black subjects

Maïmouna Touré, Diaty Sow, Arnaud JF. Tiendrébéogo, Mbaye Sène, Abdou Khadir Sow, Valentin Ouédraogo, Mor Diaw, Arame Mbengue, Modou Oumy Kane, Abdoulaye Ba, Mamadou Sarr, Abdoulaye Samb, Fatou Bintou Sar.


Background: Chronic obstructive pulmonary disease (COPD) is characterized by high mortality. The latter is strongly attributed to cardiovascular events whose onset is endothelial dysfunction and vascular remodeling.

Aims and Objectives: The aims were to evaluate the endothelial function during COPD and the factors involved with possible endothelial dysfunction in Senegalese Black men aged at least 18 years.

Materials and Methods: This was a prospective and cross-sectional study. After a complete clinical examination and evaluation of the body composition by a bioimpedancemeter, the endothelial function was evaluated by EndoPAT2000®.

Results: the mean age was 61.50 years ± 6.62. Of the subjects, 70% were smokers and 50% had limited chest enlargement. According to the body mass index and the percentage of body fat, underweight was 30% and 40%, respectively. The 75.5% of the meager could not be evaluated by bio-impedancemeter due to extreme thinness. Endothelial dysfunction involved 70% of subjects. In addition, 86% of subjects with endothelial dysfunction were smokers. The reactive hyperemia index was positively correlated with body mass index (P = 0.017 and r = 0.73), body fat percentage (P = 0.016 and r = 0.73) and visceral fat level (P = 0.008 and r = 0.78).

Conclusion: The evolution of COPD would be laced with serious cardiovascular complications often fatal. The assessment of nutritional status and endothelial function is fundamental for better management of the disease.

Key words: Chronic Obstructive Pulmonary Disease; EndoPAT2000®; Endothelial Dysfunction; Reactive Hyperemia Index; Senegalese Black Men

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