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Review Article

SRP. 2020; 11(11): 208-213


Effects of Coconut oil and fusidic acid extract in alternative traumatic wound healing in RATS model

Hassan H.K. AL Bayati, Firas A. Husseinb, Idris K. Thamer, Buthina A. Abdullahd.


Abstract

The goal of this study was to improve the appropriate and economic treatment of wounds, agency for improving injury healing processes using an animal model with the use of indigenous material such as VCO oil, we used 24 rats, they divided four groups each group (6) rats, first group (G1) treatment by coconut oil, (G2) treatment by fucine ointment, (G3) treatment by coconut oil as the first group and treated with fucine ointment and Control negative (G4) control negative, Every animal treated daily as study design in groups of 10 days. VCO group and VCO –fucine treated group wounds cured much faster than other groups, as the time for complete epithelization(10days) decreases and different skin components increase. Pepsinsoluble collagen and high level of elastin showed a significant increase in VCO–fucine groups treated the wound, indicating a higher collagen cross-linking, beside the quick effect of VCO in the re-epithelialization process and increase close examination (contraction) of the wound, Conclusion: VCO's potential advantage can be due to the combined influence of multiple small biologically active components with the power activity of fucine.

Key words: wound healing, Growth tissue, Coconut oil, fucine






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