Assessment of Serum Enzymatic Antioxidant Levels in Recurrent Aphthous Stomatitis PatientsRabbia Shabbir, Amena Rahim, Muhammad Afzal.
Objective: The objective of the study was to determine the serum enzymatic antioxidant levels in recurrent
aphthous stomatitis patients.
Study Design: This was a case control study.
Place and Duration of Study: The study was conducted in biochemistry department of Islamic International
Medical College- Trust (IIMC-T) Rawalpindi from 15 March 2016 to 14 March 2017.
Materials and Methods: The study included 160 subjects divided into two groups Aphthous group and Non-
Aphthous group. Aphthous group comprised of 70 recurrent aphthous stomatitis patients with active lesion
and 90 age and sex matched healthy controls were included in the non-aphthous group .From all the
participants 2 ml of blood was taken. Serum glutathione peroxidase levels were measured using enzyme linked
immunosorbent assay technique. This ELISA kit uses Sandwich-ELISA as the method.
Results: The comparison of mean of serum glutathione peroxidase levels between aphthous and non-aphthous
group was significant (p
Key words: Glutathione peroxidase, Oxidative stress, Recurrent aphthous stomatitis