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Original Article

J. Islam. Int. Med. Coll.. 2018; 13(3): 122-127

Does Diclofenac Sodium Provide Better Preemptive Analgesia than Ketoprofen in Impacted Third Molar Surgery? ARandomized Controlled Trial

Asma Pervaz, Kamran Khan, Jawaria Bibi.


Objective: To compare ketoprofen and diclofenac sodium as a preemptive analgesic in impacted third molar
surgery in terms of mean pain score and mean time of first analgesic postoperatively.
Study Design: Double blinded, parallel arm Randomized Controlled Trial (RCT).
th th Place and Duration of Study: The study was conducted from 15 April, 2016 to 5 November, 2016 at Oral and
Maxillofacial Surgery Department of Islamic International Dental Hospital, Riphah International University.
Materials and Methods: Eighty patients requiring surgical extraction of impacted mandibular third molar were
selected by using randomized sampling technique. These patients were randomly assigned two groups using
lottery method, resulting in sample size of 40 in each group. Preoperatively diclofenac sodium was
administered intramuscularly in group A and ketoprofen in group B using double blinded technique. Pain score
was measured 3 hours after surgery using visual analogue scale (VAS) and the time of first analgesic
consumption post-operatively was recorded in hours. Statistical Package for Social sciences (SPSS version 16)
was used for data analysis and Independent sample T test was applied to compare mean pain score and time of
first rescue analgesics between two groups with 0.05 as a level of significance.
Results: Results showed that mean pain score was less in Ketoprofen group (3.42+1.08) than diclofenac sodium
group (4.02+1.20) with significant p-value of 0.02. Time interval for first analgesic post-operatively was also
measured in hours. Results were highly significant revealing prolonged analgesic effect in Ketoprofen group
with p-value of 0.007.
Conclusion: Preemptive Ketoprofen provides better and prolonged pain control as compared to Diclofenac
Sodium in impacted third molar surgery.

Key words: Diclofenac Sodium, Ketoprofen, Preemptive Analgesia, Pain Score.

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