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Case Report

Med Arch. 2021; 75(3): 237-238


Clinical Insights on Pre- and Novel Postconditioning in Equine Jejunal Ischemia

Ilker Sengul, Demet Sengul.




Abstract

Conditionings still remain as one of the challenging, attractive, and mysterious issues in reperfusion injury, to date. Murry and colleagues (1) introduced the concept of ischemic preconditioning (IPC), i.e. the repetitive brief episodes of ischemia in order of rendering the myocardium more resistant to a subsequent prolonged ischemic insult that causes irreversible injury in 1986. In 2003, the Vinten-Johansen Laboratory of Cardiothoracic Surgery reported a canine coronary artery occlusion-reperfusion experimental model, that termed as ischemic postconditioning (IPoC), in which a similar regimen of brief episodes of ischemia carried out just after, instead of just before, revealing the reduced infarct size, coronary artery endothelial dysfunction, and neutrophil accumulation in the area at risk (2).

Key words: Jejunal Ischemia






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