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SRP. 2020; 11(6): 445-448

The Practicability of the Application of Vitamin D in Combination with Vitamin K for the Improvement of Bone Tissue Metabolism

Malyugina O.A., Markov A.A..


This work is dedicated to the explication of practicability of application of vitamin D in combination with vitamin K for the improvement of bone tissue metabolism. Actuality of this work is justified by the growth of number of low energy fractures in patients with osteopenic syndrome caused by the decrease of bone tissue mineral density (BTMD). Silent continuous epidemic of osteoporosis leads to more profound consideration of bone tissue metabolism, looking for application points of pharmacological substances for the prevention and treatment of BTMD. Vitamin D improves the absorption of calcium, increases its excretion by the kidneys, but vitamin K is necessary for following effective inclusion of ions of Calcium into the bone tissue matrix. Gla-protein obtains ability to bind calcium as a result of K-dependent carboxylation thereby maintaining and increasing density of bone tissue. The conclusion based on results of the research can be made about the rationality of combination of vitamin D and vitamin K for positive influence on the bone tissue metabolism and for decline of risk of low energy fractures development in patients with osteopenic syndrome.

Key words: Vitamin D, Vitamin K, Bone Tissue Mineral Density, Osteocalcin, Bone Tissue Metabolism

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