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Association of polymorphisms of xeroderma pigmentosum complementation group D gene with cervical cancer in Maharashtrian population: A case-control study

Kalpita S Korabu, Kailas D Datkhile, Madhavi N Patil, Pratik P Durgawale, Shreepad A Joshi, Satish V Kakade.


Background: Maharashtrian population is at the risk of cervical cancer (CC) and is not subjected to investigate the cancer susceptibility in association with genetic determinants.

Objectives: This study was aimed to evaluate the association of single nucleotide polymorphisms (SNPs) in DNA repair gene xeroderma pigmentosum complementation group D (XPD) with CC risk from rural Maharashtra.

Materials and Methods: We used polymerase chain reaction and-restriction fragment length polymorphism to analyze SNPs in XPD gene from 350 patients with CC and 400 age and sex-matched disease-free controls.

Results: The results indicated no significant difference in the genotype distribution between CC patients and controls for the XPD gene at codon 156 of exon 6 and codon 751 of exon 23, but the results showed that allele frequencies of XPD Asn 312 of codon 312 of exon 10 (odds ratio = 0.31; 95% confidence intervals = [0.16–0.63]; P =

Key words: Cervical Cancer; Genetic Polymorphism; Xeroderma Pigmentosum Complementation Group D; Polymerase Chain Reaction and Restriction Fragment Length Polymorphism

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