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Original Article

Quantitative analysis of the factors influencing IDA and TSH downregulation in correlation to the fluctuation of activated vitamin D3 in women

Salauddin Al Azad, Sharmin Ahmed, Partha Biswas, Md. Abdur Rashid Mia, Mithila Farjana, Farzana Alam Arshe, Sabrina Jahan Mily, Ananya Baidya Ankhi, Mahdi Mubin Shaikat, Sabeeha Sultana, Kashfia Mawa, Zannatul Naim, Md. Ataur Rahman, Bonglee Kim.


Anemia and thyroid disorders are global health issues that affect all ages but are more apparent in women. In this case, some serological components responsible for IDA and TSH downregulation in women have been found actively regulated through a complex vitamin D3 mediated mechanism. This research has been investigated the correlation between activated vitamin D3 and the serological components responsible for iron deficiency anemia (IDA) and dysregulation of TSH in childbearing and non-child-bearing women of different health conditions. Experimental sampling from 482 women suffering from both IDA and TSH dysregulation was taken, aged between 0 and 70 years. Serological parameters, such as iron, total iron-binding capacity, and ferritin, were assessed for IDA profiling, whereas thyroid-stimulating hormone and free thyroxin were for TSH profiling based on the individual’s serum vitamin D3 concentration. The resulting serological data were interpreted using sophisticated computer programming language and algorithms for quantitative biochemical analysis. The study resulted in a significant correlation between FT4 and vitamin D3 (p < 0.0001) for all age groups. TSH also showed strong interactions with the fluctuation of vitamin D3 level (p < 0.0001), except for the children aged below 10 years (p < 0.063). The iron, TIBC, TSH, and FT4 showed phenomenal regulation with the steroidal-vitamin D3 concentration for congenital patients. Unlike the others, ferritin has a substantial connection with activated Vitamin D3 (p < 0.0064) fluctuation in the serum. To ratify, the concentrations of TSH, FT4, iron, TIBC, and ferritin were found to be significantly interconnected in terms of serum vitamin D3 concentration in women suffering from IDA and TSH downregulation simultaneously. In addition, the BMI condition of the patients can be a major factor in terms of correlating vitamin D3 with the regulatory factors of IDA and thyroid TSH as resulted in this research. To understand the accuracy and efficacy of the serum vitamin D3 in IDA and TSH downregulation, some other inflammatory markers and parathyroid hormone analysis of a large number of samples can be conducted in continuation of this study.

Key words: IDA, TSH downregulation; activated vitamin D3 concentration; BMI; reproductive and non-reproductive women; quantitative assessment of the serological factors

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