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Synergistic antimicrobial activity of honey combined with silver nanoparticles topically applied in experimentally infected wounds in Wistar albino rats

Neeraja Rani Guruvu, Venkatanarayana Narapogu, D Lakshmi Lalitha, Bandaru Narasinga Rao Bandaru, Sai Sailesh Kumar Goothy, D Murali Mohan Rao.


Background: Silver nanoparticles (AgNPs) show ample antibacterial activities when combining with honey.

Aim and Objective: The study was designed to determine the antibacterial activity of different kinds of honey against the common wound pathogen Staphylococcus aureus.

Materials and Methods: Bacterial strain was used to inoculate the wound. S. aureus ATCC-25923 was used in the study.

Results: Wound infection examination was done by total count of bacterial load. In all three groups, better percentage of the wound closer, histological, blood, and tissue parameters identified in honey combine with AgNPs, showed a synergistic effect.

Conclusion: Honey and AgNPs showed synergistic effect. It is recommended to apply both the products together.

Key words: Honey; Silver Nanoparticles; Staphylococcus aureus; Blood and Tissue Parameters

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