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Research Article

JCDR. 2022; 13(1): 496-505

Comparative Study on Diurnal Variation of Intraocular Pressure among Patients with Asymmetric Primary Open Angle Glaucoma and without Glaucoma at a Tertiary Eye Care Centre, Kolkata, India



The Glaucomas are a group of progressive optic neuropathies associated with corresponding visual
field defects where IOP is a major modifiable risk factor and is the leading cause of irreversible
blindness worldwide.
This study was conducted to compare the diurnal variation of Intraocular pressure (IOP) among
patients with asymmetric primary open-angle glaucoma and without glaucoma and to determine the
influence of age, sex, diabetes, hypertension, and anti-glaucoma drugs over diurnal variation of IOP.
Settings and Design:
This prospective randomized comparative study was done at the Glaucoma Clinic at the Regional
Institute of Ophthalmology, Medical College and Hospital, Kolkata from January 2018 to August
Methods and Material
The patients were categorized by Cases (all asymmetric POAG patients, 80 eyes) and Control (all 80
non-glaucomatous eyes). After taking history and clinical examinations, Central Corneal Thickness
(CCT) corrected IOP was measured from 7 am to 7 pm at 2 hourly intervals before starting therapy.
Cases were treated with either Timolol 0.5% twice daily or Topical Travoprost 0.004%once daily (9
pm). Follow-up examinations were done at 1month and 3 months.
Statistical Analysis:
Statistical Analysis was performed with Epi Info (TM) 3.5.3 software, USA. Standard statistical tests
were applied where applicable. t-test was used to compare the Mean. p ≤0.05 was considered
statistically significant.

Key words: Asymmetric glaucoma, Diurnal variation, Timolol maleate, Travoprost

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