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Review Article

JCR. 2020; 7(4): 376-377


SPECIAL PATHOMORPHOLOGICAL CHANGES IN CHILDREN WITH LYMPHOCYTIC LEUKEMIA

Zulfiya Salayeva, Roza Masharipova, Parokhat Aliyeva, Gulsara Jumanyazova, Gulnora Shamuratova.

Abstract
First of all, leukemia cells appear in the organ stroma, then infiltrate the parenchyma. Acute lymphblastic leukemia in children is the most common cancer in children aged 2-5 years. The main clinical and morphological sign is the large production of lymphocytic cells from the bone marrow. The disease is very severe and often leads to death. It is therefore important to identify and recognize the initial signs of the disease. Every year, 50 out of a million children are infected with the disease.Blood and lymph tissue tumours account for half of all malignant tumours, of which between 38 and 40% are leukemia. Of the 100,000 children under the age of 15, 4.1 0.4 suffer from acute lymphocytosis, with boys and girls at a ratio of 1.3 to 1, and 2 to 5 years at most. Modern diagnosis of acute lymphocytosis is based on the FAB classification, whose main criterion is morphological and cytological confirmation of blood vessels. In the sample of bone marrow from 25 to 30% of blasts were diagnosed with acute leukemia, with 3 types of cells identified: L1, L2, L3. 85% of acute lymphblastswere L1, 14% L2, and 1% L3.The main diagnostic method is cytomorphology. Trepan biopsy should be obtained from the iliac bones, and the diagnosis is confirmed by the presence of poorly differentiated blast cells in the histological preparation.

Key words: path morphological, lympholecosis, tissue tumours, cytomorphology, lymphocytic, polyclinic.



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