Abstract

Cognitive impairments continue during the symptomatic period and remission in patents with major depressive disorder. Sexual dysfunctions may be seen in depression and also represent a frequent side effect of antidepressant treatment and one of the major reasons for early discontinuation of medications. Case Report: In this case report we present a 38-year-old female patient who experienced a side effect while receiving treatment for major depression. The patient was switched to vortioxetine 10 mg/day after 3 months of treatment with fluoxetine 40 mg/day due to continuing cognitive dysfunction and antidepressant-associated decreased libido. The patient developed an extensive purpuric rash on the anterior thighs on the third day of the treatment. The treatment was discontinued. The same side effect occurred after the re-initiation of vortioxetine treatment at a dose 5 mg/day. Reporting of observed side effects may be useful for clinicians since the number of case reports on vortioxetine is limited.

Key words: vortioxetine, depression, purpura