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Research Article

JCDR. 2022; 13(1): 666-673


To Evaluate the Conventional and Advanced Brain MR Imaging in Patients with Sickle Cell Anemia: A Cross Sectional Study

Narendra Singh Patel, Vishal Singh Rathor, AvadheshPratap Singh Kushwah, Sonjjay Pande.


Abstract

Background:To evaluate the conventional and advanced brain MR imaging in patients with
sickle cell anemia.Material and Methods:This prospective observational case–control study
included 70 SCD (SCA 45, SCT 25) cases having no neurological problem and 60 healthy
controls. The control group included Male subjects of the age 10-45, whereas female subjects
were 15-50 years old. The SCA and SCT male and female participants were of age group 11-
30years, 15-45 years and 14-40 years, 15-55 years respectively.Results:The average of all
ROIs of different regions in SCD, SCT, and control were taken out. The FA values showed a
statistically significant difference between patients with SCD and control subjects in CC genu
(0.62 vs 0.68, P = 0.004), splenium (0.61 vs 0.67, P = 0.005), left centrum semiovale (0.43 vs
0.49, P = 0.001), anterior periventricular white matter left side (0.40 vs 0.47, P = 0.008),
posterior periventricular white matter left side (0.38 vs 0.49, P = 0.005), pons left (0.43 vs
0.51, P = 0.001), head of caudate nucleus left (0.31vs 0.63, P = 0.001), and lentiform nucleus
left (0.32 vs 0.52, P = 0.001). ADC values showed a statistically significant difference
between patients with SCD and control subjects in the CC genu (0.93 vs 0.85, P = 0.001),
right caudate nucleus (0.86 vs 0.79, P = 0.001), left caudate nucleus (0.87 vs 0.79, P = 0.001),
left thalamus (0.85 vs 0.81, P = 0.001),and right and left pons (0.88 vs 0.84, P = 0.014 and
0.88 vs 0.84 P = 0.018).Conclusion:Decrease in FA and increase in ADC found in various
brain regions without visible signal intensity changes on conventional MRI in patients with
SCD are associated with microstructural changes consistent with axonal damage due to
vasculopathy

Key words: Sickle cell anemia, brain MR imaging






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