Home|Journals|Articles by Year

Directory for Medical Articles

Original Article

JCDR. 2018; 9(4): 177-181

Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12 and Pulse Pressure Value in Coronary Artery Disease Patients

Deeraj Mungun, Xiang Ming Wang, Iyan Zakariya, Lu Miao, Tian Tian Tu, Yan Guo.


Objective: Coronary artery disease (CAD) causes more than 1 million deaths in China annually. The incidence of coronary
artery disease tends to increase in the middle age and elderly people. Pulse pressure is associated with increased risk
of CAD in middle-aged and older subjects, whereas soluble receptor for advanced glycation end products (sRAGE) and
S100A12 are involved in pathology of atherosclerosis. In this study, we examine the associations of the expression level
of sRAGE, S100A12 and PP value in both CAD and non-CAD groups; thus, providing more comprehensive strategies
on preventing CAD. Method: Selected were divided into two main groups based on their angiograph results: CAD
group (patients with at least one coronary artery of more than 50% occlusion) and Non-CAD Group (patients with less
than 50% occlusion or without coronary artery occlusion). Soluble RAGE (sRAGE) and S100A12 concentration in blood
samples were collected before CAG procedure were measured using ELISA. Pulse Pressure was measure from the
difference between SBP and DBP. Results: Significant decrease in concentration of serum sRAGE (p

Key words: Serum soluble receptor for advanced glycation end products (sRAGE), S100A12, Pulse Pressure, Coronary Artery Disease (CAD).

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.