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Original Article

. 2018; 9(4): 177-181


Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12 and Pulse Pressure Value in Coronary Artery Disease Patients

Deeraj Mungun, Xiang Ming Wang, Iyan Zakariya, Lu Miao, Tian Tian Tu, Yan Guo.

Abstract
Objective: Coronary artery disease (CAD) causes more than 1 million deaths in China annually. The incidence of coronary
artery disease tends to increase in the middle age and elderly people. Pulse pressure is associated with increased risk
of CAD in middle-aged and older subjects, whereas soluble receptor for advanced glycation end products (sRAGE) and
S100A12 are involved in pathology of atherosclerosis. In this study, we examine the associations of the expression level
of sRAGE, S100A12 and PP value in both CAD and non-CAD groups; thus, providing more comprehensive strategies
on preventing CAD. Method: Selected were divided into two main groups based on their angiograph results: CAD
group (patients with at least one coronary artery of more than 50% occlusion) and Non-CAD Group (patients with less
than 50% occlusion or without coronary artery occlusion). Soluble RAGE (sRAGE) and S100A12 concentration in blood
samples were collected before CAG procedure were measured using ELISA. Pulse Pressure was measure from the
difference between SBP and DBP. Results: Significant decrease in concentration of serum sRAGE (p

Key words: Serum soluble receptor for advanced glycation end products (sRAGE), S100A12, Pulse Pressure, Coronary Artery Disease (CAD).


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