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Review Article

. 2018; 9(1): 1-4


Breast Cancer and the Heart: Burden on the Chest

Ajit Singh, Hashir Kareem, Tom Devasia, Kanav Khera, Sheetal Chauhan, Yeswanth Rao K, Ganesh P.

Abstract
Breast cancer survivors after successful treatment face various complications in their life. These problems are related
to their psycho-social life and/or related to altered body image or may be because of the side effects of breast cancer
therapy. Different types of treatment show various hemodynamic/physiological changes on one or more organ/systems.
Cardiovascular is the mainly affected system after breast cancer treatment. Radiation-induced heart diseases (RIHD)
involve a broad cardiac pathology comprising myocardial fibrosis and cardiomyopathies, pericardial disease, valvular heart
diseases, arrhythmias and coronary artery diseases. Chemotherapy induced cardiotoxicity (CIC) affects the morbidity
and mortality in breast cancer survivors. Regardless of cancer prognosis; it impacts the quality of life and overall survival
with major limitations in life. Conventional diagnostic procedures and biomarkers can be used to detect RIHD and CIC.
Cardio-oncology helps in filling the gap between cardiologist and oncologist to reduce the future cardiac risk in survivors.

Key words: Radiotherapy induced heart disease (RIHD), Chemotherapy induced cardiotoxicity (CIC), Modified radical mastectomy (MRM), Ultrasound tissue characterization (UTC), Myocardial fibrosis.



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