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Original Article

. 2016; 7(3): 116-119

Investigation of P-Wave Dispersion in Adult Patients with Beta-Thalassemia Major

Sajad Amirghofran, Amir Aslani, Maryam Zakerinia.

Background: Paroxysmal atrial tachyarrhythmias, especially atrial fibrillation is a fatal complication that occur more frequently
in patients with β-thalassemia major (β-TM) than normal population. This study aimed to compare P-wave dispersion
(PWD) in patients with β-thalassemia major with control subjects for the early prediction of arrhythmia risk. Methods:
Sixty-six adult patients with β-TM referring to Shahid Motahari hospital of Marvdasht in winter 2015 were compared
to 50 non-thalassemic adults. All participants underwent routine 12-leads electrocardiography (ECG) for cardiac evaluation.
ECGs were scanned and PWD was calculated as the difference between the maximum and the minimum P-wave
duration. Results: Patients with β-TM aged between 18 to 47 years old and were matched by age and gender to the
control group. There was a statistically significant difference between the study and control groups in minimum P-wave
duration (44.89.8 vs 49.15.3 ms, p=0.006), maximum P-wave duration (105.312.5 vs 97.66.4 ms, p

Key words: Electrocardiography, PWD, beta-Thalassemia, Atrial Fibrillation, Iron Overload.

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