The potential impact of family history of loud Snoring and risk of Obstructive sleep apnea in overweight subjects.Abhishek Dubey, Surya Kant, Abbas Ali Mahdi, Sunita Tiwari, Rashmi Upadhyay, Snehal Upadhyay.
Context: Central obesity, increased neck circumference are strong established risk factors of OSA. Familial aggregation
is less explored potential risk factors. Aims: To compare sleep, metabolic parameters and risk of OSA in subjects with
and without history of loud snoring in first degree blood relatives. Settings and Design: Cross-sectional tertiary hospitalbased
study Methods and Material: Overweight subjects (body mass index >25 kg/m2 aged 18-65 yrs were selected
using systematic random sampling from attendants of patients attending Pulmonary Medicine OPD .On the basis of
inclusion and exclusion criteria,380 subjects were enrolled, inquired about Loud Snoring in their first degree blood
relatives and full night study, fasting serum lipid profile, plasma glucose level estimation was carried out after taking
informed/written consent. Statistical analysis used: Statistical analysis was performed using SPSS 20. Student t test was
applied for comparing mean values of various variables between two groups. Fisher test was applied for estimation of
odd ratio (OR). Results: Neck circumference (p value .01), AHI value (p value .01) and fasting plasma glucose levels
(p value .04) were found significantly higher in subjects with positive history of loud snoring in any first degree blood
relative . Increased but insignificant risk (P value 0.15) of OSA (defined as AHI
Key words: Familial aggregation, Obstructive Sleep Apnea , Obesity, snoring.