Diabetes is an important risk factor for atherosclerosis. The diabetic foot is characterized by the presence
of arteriopathy and neuropathy. The vascular damage includes non-occlusive microangiopathy and
macroangiopathy. Diabetic foot wounds are responsible for 5e10% of the cases of major or minor amputations.
In fact, the risk of amputation of the lower limbs is 15e20% higher in diabetic populations than
in the general population. The University of Texas classification is the reference classification for diabetic
wounds. It distinguishes non-ischemic wounds from ischemic wounds which are associated with a
higher rate of amputation. The first principles of treatment are the control of pain of an eventual
infection. When ischemia is diagnosed, restoration of pulsatile blood flow by revascularization may be
considered for salvaging the limb. The treatment options are angioplasty with or without stenting and
surgical bypass or hybrid procedures combining the two. Distal reconstructions with anastomosis to the
leg or pedal arteries have satisfactory limb-salvage rates. Subintimal angioplasty is a more recent
endovascular technique. It could be suggested for elderly patients who are believed to be unsuitable
candidates for a conventional bypass or angioplasty. The current article would focus on the various
Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity.
Ferrari F, Moretti A, Villa RF
Neural regeneration research. 2022; 17(2): 292-299
Assessment of structural brain changes in patients with type 2 diabetes mellitus using the MRI-based brain atrophy and lesion index.
Zhao H, Wang F, Luo GH, Lei H, Peng F, Ren QP, Chen W, Wu YF, Yin LC, Liu JC, Pan SN
Neural regeneration research. 2022; 17(3): 618-624
The Importance of Experimental Investigation of the Peripheral Oxytocin System.
Methods in molecular biology (Clifton, N.J.). 2022; 2384(): 1-27
Diabetes mellitus and Parkinson's disease: dangerous liaisons between insulin and dopamine.
De Iuliis A, Montinaro E, Fatati G, Plebani M, Colosimo C
Neural regeneration research. 2022; 17(3): 523-533
Methods to Analyze the Effect of Diet-Derived Metabolites on Endothelial Inflammation and Cell Surface Glycosaminoglycans.
Cutler BR, Chua JS, Balagurunathan K, Anandh Babu PV
Methods in molecular biology (Clifton, N.J.). 2022; 2303(): 469-476