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Research Article

JCDR. 2021; 12(4): 293-297


Role of C- reactive protein as an inflammatory marker in sputum smear positive pulmonary tuberculosis patients

Dr.Jasbir Singh, Dr.Kailash Meena, Dr.Surinder Pal Singh, Dr.Harjinder Singh,Dr.Ajaypal Singh.


Abstract

Background: Pulmonary tuberculosis is associated with local inflammation of the lung tissue andincreases the
levels of the inflammatory markers. C – Reactive protein is an important inflammatory marker during
pulmonarytuberculosis. The aims of our study were measuringserum CRP level in sputum smear-positive
pulmonary tuberculosis patients at the start and end of the intensive phase of anti-tubercular therapy (ATT)
along with correlation between sputum smear grading and serumCRP level at the start and end of intensive
phase of ATT.
Methods: This was aprospective cohort study and60 patientswithsputum smear-positive pulmonary
tuberculosiswere taken. Serum CRP level and sputum smear grading wasdone at the start and end of the
intensive phase of ATT.
Results: SerumCRP level before the start and at end of intensive phase of ATT showed mean of 11.72 ± 5.53
mg/dl (males - 11.01 ± 5.25, females - 12.77 ± 5.89) and 2.69 ± 1.81mg/dl(males -2.66 ± 1.87, females - 2.72
± 1.75), respectively. On statistical analysis, the p-value was

Key words: Pulmonary tuberculosis,C - reactive protein,Anti-tubercular therapy,Intensive phase






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