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Research Article

. 2019; 7(3): 295-329

Bioadhesive Nanoformulations—Concepts and Preclinical Studies: A Critical Review

Monika Joshi, Ravi Shankar, Kamla Pathak.


In the past few decades continuous and successful development of various nanomaterials has caused revolution due to the gained prominence in technological advancements and their industrial applications. On the other hand, the work on bioadhesive systems has gained prominence as these systems can adhere to mucus which is present in almost all organs of the body and can reside there for long periods of time, increasing local/systemic bioavailability of the drug. Thus, the emergence of nanosystems together with this non-invasive and trouble-free route has attracted the researchers' interest with the aim to maintain high patient compliance and the possibility to dramatically modulate the pharmacokinetics of the active pharmaceutical ingredients. This review highlights the significance and various types of nanoformulations developed along with basics of bioadhesion, polymers used for bioadhesion and various research reports showing development of bioadhesive nanoformulations for various pharmaceutical applications.

Key words: Bioadhesion, nanoformulations, oral, parenteral, bioavailability

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