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Research Article

. 2019; 7(1): 51-67


Chitosan-Catechol Conjugates–A Novel Class of Bioadhesive Polymers: A Critical Review

Loveleen Kaur, Inderbir Singh.


Abstract

Chitosan-catechol conjugates are a novel class of bioadhesive polymers which are used in specific/target drug delivery systems to bind the drug to the mucosal lining. Preparation of chitosan-catechol conjugates by chemical, electrochemical and enzymatic methods has been discussed. Different characterization techniques viz Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD) have also been discussed. Various properties such as solubility, stability, permeation, mucoadhesion, antibacterial, mechanical strength, biocompatibility and bioink relating to the potential applications of chitosan-catechol conjugates have been elaborated. Patent updates with the future perspectives of the conjugates have also been presented. Chitosancatechol conjugates have been presented as a novel class of bioadhesive polymers that could be utilized for developing mucoadhesive drug delivery systems.

Key words: Mucoadhesion, chitosan, catechol, chitosan-catechol conjugate






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