Control of Biofilm at the Tooth-Restoration Bonding Interface: A Question for Antibacterial Monomers? A Critical Review
Mary Anne S. Melo, Michael D. Weir, Fang Li, Lei Cheng, Ke Zhang, Hockin H. K. Xu.
Oral biofilm formation is of great concern in several multidisciplinary fields, especially in Medicine and Dentistry. Dental caries is a biofilm-dependent disease that destroys teeth and presents high incidence around dental fillings. Antibacterial monomers are considered as a promising anti-biofilm approach in the dental materials field. The process of adding a new functionality to constituents of tooth-restoration bonding materials by changing the chemistry of the material may prevent oral bacteria biofilm formation, infiltration, and proliferation. The use of antibacterial monomers offers promise for minimizing the toxicity problems and allowing a long lasting effect of the antimicrobial agents. While considerable progress has been made in the design of antibacterial monomers, ongoing research in this area should result in the development of even better anti-biofilm dental bonding materials in the future. In this review, current activities in the development of dental primers and adhesives containing quaternary-ammonium based monomers, challenges faced in reaching ideal antimicrobial activity, and potential of such monomers against dental caries are highlighted.
Key words: Antibacterial monomers, dental materials, dental caries, dental bonding