Nontraumatic acute subdural hematoma is rare, and no associations with the COVID-19 vaccine have been reported. This report presents the case of a 77-year-old woman who developed a nontraumatic acute subdural hematoma eight days after vaccination with the BNT162b2 COVID-19 vaccine. The patient took 50 mg/day of clopidogrel and was diagnosed with a severe acute subdural hematoma and brain herniation at admission. Although the BNT162b2 vaccine has not been determined as a risk factor, intracranial haemorrhage has been reported in Japan after its administration. Nontraumatic acute subdural hematoma may be an extremely rare adverse event of the BNT162b2 vaccine, but more data may be needed to confirm this.
Key words: nontraumatic, acute subdural hematoma, COVID-19, vaccination, BNT162b2
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