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Research Article

JCDR. 2021; 12(4): 195-203


FORMULATION AND EVALUATION OF MICROSPHERE EPIVIR (TABLET) IN HIV DISEASE

DEEPAK KUMAR, ANKIT KUMAR, SURYAKANT VERMA, DR. SACHIN TYAGI, HIMANSHU KUMAR, MOHIT PANWAR.


Abstract

OBJECTIVE: The Epivir controlled-release tablets manufactured in several combinations utilising a direct
compression procedure with variable amounts of Carboplol974P and Xanthan gumps. The amount and concentration
of RRDs, Carboplol974P and Xanthan gum needed for the desired release of the drug were chosen as independent
factors x1 and x2; while the 10% drug-dissolution time required was 10%, t50% to75%, t90%, dependent variables
picked
METHODS:
RESULT: Nine formulations for hardness, friction, thickness, percentage of medication, in-vitro release were
created and analysed. The results show that all pharmacopeia-limited formulations and all formules with in vitro
dissolution profiles have been match the model of kinetic computing statistical parameter such as intercept (a), slope
(b) and regression coefficient (r). equation like Polynomial for T10 percent, T50 percent, T75 percent, T90 percent
determined.
CONCULSION:
Here more over similar formulation (f2=85.04& No more differential t=0.2005) according to the SUPAC guidelines
is the formula including a combination of 10 percent Carboplol974P and 10 percent gum Xanthan (FDK5)
(Lamivir). formulation selected on (FDK5) based on Higuchi's kinetics and the drug-release mechanism established
as a case- II or a standard Zero release (Non-Fickian, n = 0.915).

Key words: The Epivir controlled-release tablets manufactured in several combinations utilising a direct compression procedure with variable amounts of Carboplol974P and Xanthan gumps.






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