Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Review Article

SRP. 2020; 11(2): 507-509

The Role of Interleukin-6 (IL-6), Interleukin-10 (IL- 10), Plasminogen Activator (PAA), and Plasminogen Activator Inhibitor (PAI) Towards the Occurence of Peritoneal Adhesions in Post-Laparotomic Patients

M. Alsen Arlan, Ponpon S Idjradinata, Suwandi Sugandi, Tri Hanggono Achmad.

Background: Peritoneal adhesion is still becoming one of the most common postoperative complications which increases the rate of morbidity and mortality. The process which leads to the formation of peritoneal adhesion is depending on the balance between the pro-inflammatory and anti-inflammatory processes, in which there are roles of Interleukin-6 (IL-6) and Interleukin-10 (IL-10) as well as the balance of fibrinolysis process played by Plasminogen Activator (PAA) and Plasminogen Activator Inhibitor (PAI) .
Objective: This research is to study the relationship between the ratio of IL-6 to IL-10, as well as the ratio of PAI to PAA with the incidence of peritoneal adhesion after laparotomy procedure.
Method: The study was conducted using comparative experimental case study by treating two randomly selected groups using randomised controlled trial method. Group 1 was patients who underwent laparotomy procedure and were given ketorolac tromethamine which is analgesic that had anti-inflammatory effects, compared to group 2 which act as a control group and were given tramadol, a pure analgesic drug. The subjects of this study were patients who undergoes stoma procedures (colostomy, ileostomy) due to colon perforation as a result of trauma or other diseases
Results: Correlation analysis that was conducted revealed significant interaction between IL-10 with PAA while there were no significant association recorded between IL-10 with IL-6 and PAI as well as IL-6 and PAA.
Conclusions: There is a significant interaction between the levels of IL-10 and PAA with the occurrence of peritoneal adhesion in post-laparotomy patients.

Key words: IL-6; IL-10; PAI; PAA

Similar Articles

FGL1 as a modulator of plasma D-dimer levels: exome-wide marker analysis of plasma tPA, PAI-1 and D-dimer.
Thibord F, Song C, Pattee J, Rodriguez BAT, Chen MH, O'Donnell CJ, Kleber ME, Delgado GE, Guo X, Yao J, Taylor KD, Ozel AB, Brody JA, McKnight B, Gyorgy B, Simonsick E, Leonard HL, Carrasquilla GD, Guindo-Martinez M, Silveira A, Temprano-Sagrera G, Yanek LR, Becker DM, Mathias RA, Becker LC, Raffield LM, Kilpeläinen TO, Grarup N, Pedersen O, Hansen T, Linneberg A, Hamsten A, Watkins H, Sabater-Lleal M, Nalls MA, Trégouët DA, Morange PE, Psaty BM, Tracy RP, Smith NL, Desch KC, Cushman M, Rotter JI, de Vries PS, Pankratz ND, Folsom AR, Morrison AC, März W, Tang W, Johnson AD
Journal of thrombosis and haemostasis : JTH. 2021; ():

The Influence of Service Era: Comparing Personality Assessment Inventory (PAI) Scale Scores Within a Posttraumatic Stress Disorder Treatment Clinic (PCT).
Ingram PB, Morris NM, Golden B, Youngren WA, Fulton JA, Sharpnack J
Journal of clinical psychology in medical settings. 2021; ():

Aldoximes are precursors of auxins in Arabidopsis and maize.
Perez VC, Dai R, Bai B, Tomiczek B, Askey BC, Zhang Y, Rubin GM, Ding Y, Grenning A, Block AK, Kim J
The New phytologist. 2021; ():

Transgenic Mice With Augmented n3-Polyunsaturated Fatty Acids Are Protected From Liver Injury Caused by Acute-On-Chronic Ethanol Administration.
Warner J, Hardesty J, Song Y, Sun R, Deng Z, Xu R, Yin X, Zhang X, McClain C, Warner D, Kirpich I
Frontiers in pharmacology. 2021; 12(): 711590

Diversity of Epithelial-Mesenchymal Phenotypes in Circulating Tumour Cells from Prostate Cancer Patient-Derived Xenograft Models.
Hassan S, Blick T, Thompson EW, Williams ED
Cancers. 2021; 13(11):

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites