The article examines the directions of improving the "triple helix" system in the current conditions of a pandemic. The basis of the process is the generation of knowledge by national research centers, universities, with direct support from the authorities and constructive interaction with business. The modern contour of this spiral ensures the development and implementation of innovative domestic developments, methods and technologies, expands the possibilities for the treatment of various diseases by introducing new equipment and pharmaceuticals. The key element of the system is the introduction to the market of the results of intellectual activity, carried out through the prompt implementation of science-intensive technologies and industries in all spheres, complexes and sectors of the country's economy. The results of effective realization of the potential of the "triple helix" model in the first city of science - Obninsk and Kaluga region are demonstrated. Examples of developments of scientific organizations that are part of innovative clusters are given, which made it possible to formulate a treatment regimen for diseases in the shortest possible time, create the necessary drugs, and apply them in the realities of the spread of coronavirus infection. The authors substantiate the opinion that an adequate response to emerging dangerous challenges is prepared in advance, thanks to the conduct of active research activities, and an effectively formed "triple helix" system acts as a guarantor of the successful implementation of intellectual activities that can save the lives of millions of people.
Key words: triple helix model, innovation clusters, science city Obninsk regional development, pandemic, quality of life.