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JCDR. 2022; 13(1): 646-651

Comparative evaluation of serum lipid levels in COVID-19 patients before and after therapy

Manoj Kumar, Dr Granth Kumar, Pankaj Kumar, Vidya Sagar Ram, Shushil Kumar Yadav, Shashi Ahirwar.


Aims of this study were to investigate the pathological alterations in LDL-cholesterol, HDLcholesterol,
total cholesterol, and triglycerides in individuals with COVID-19 infection.
Methods:Between February and April 2020, a total of 80 COVID-19 patients admitted to our hospital
and 80 patient recovered from COVID-19 were evaluated for their LDL- and HDL-cholesterol levels.
80 age and sex matched individual were included in the study for comparision. Lipid level were
compared among the COVID-19 patient, patient recovered from COVID-19 and healthy control.
Results:Over eighty percent of the covid-19 patients had cholesterol levels that were much lower than
the normal person. Only total cholesterol indicated significant differences between healthy controls
and COVID-19. There was a considerable increase in the levels of HDL, LDL (bad), and triglyceride
levels after recovery compared to the acute stage of sickness. Low density lipoprotein (LDL)
cholesterol and total cholesterol had a negative relationship with C-reactive protein (CRP). It is
possible that lipids such as cholesterol are important in viral multiplication, internalisation and
immunological activation in COVID-19 infected individuals, according to our data.
Conclusions: In addition, it is possible to use lipid abnormalities discovered during and after infection
as a proxy for assessing the effectiveness of therapeutic treatment.

Key words: COVID-19; (SARS-CoV-2); total cholesterol; high-density lipoprotein (HDL)- cholesterol; triglycerides

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