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Research Article

JCDR. 2022; 13(1): 646-651


Comparative evaluation of serum lipid levels in COVID-19 patients before and after therapy

Manoj Kumar, Dr Granth Kumar, Pankaj Kumar, Vidya Sagar Ram, Shushil Kumar Yadav, Shashi Ahirwar.


Abstract

Introduction:
Aims of this study were to investigate the pathological alterations in LDL-cholesterol, HDLcholesterol,
total cholesterol, and triglycerides in individuals with COVID-19 infection.
Methods:Between February and April 2020, a total of 80 COVID-19 patients admitted to our hospital
and 80 patient recovered from COVID-19 were evaluated for their LDL- and HDL-cholesterol levels.
80 age and sex matched individual were included in the study for comparision. Lipid level were
compared among the COVID-19 patient, patient recovered from COVID-19 and healthy control.
Results:Over eighty percent of the covid-19 patients had cholesterol levels that were much lower than
the normal person. Only total cholesterol indicated significant differences between healthy controls
and COVID-19. There was a considerable increase in the levels of HDL, LDL (bad), and triglyceride
levels after recovery compared to the acute stage of sickness. Low density lipoprotein (LDL)
cholesterol and total cholesterol had a negative relationship with C-reactive protein (CRP). It is
possible that lipids such as cholesterol are important in viral multiplication, internalisation and
immunological activation in COVID-19 infected individuals, according to our data.
Conclusions: In addition, it is possible to use lipid abnormalities discovered during and after infection
as a proxy for assessing the effectiveness of therapeutic treatment.

Key words: COVID-19; (SARS-CoV-2); total cholesterol; high-density lipoprotein (HDL)- cholesterol; triglycerides






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